Cancer induced bone pain as a result of bone metastases strongly interferes with quality of life and daily functioning of patients with advanced cancer. The current standard of care for patients with painful bone metastasis includes palliative external beam radiotherapy (EBRT). While EBRT is a well-established treatment option, it takes up to 4-6 weeks for EBRT to induce optimal pain relief, and 30-40% of patients do not respond to EBRT.
Pain palliation may be substantially improved by including magnetic resonance image guided high intensity focused ultrasound (MR-HIFU) as alternative or in addition to EBRT. Until now, no studies have been conducted in which EBRT and MR-HIFU have been compared as a first-line treatment in patients with painful metastatic bone disease. Thus, strong evidence and context is lacking for wide-spread implementation of MR-HIFU into routine care.
The FURTHER study aims to provide the evidence base to stimulate the uptake of MR-HIFU as a first line treatment option in clinical guidelines for the treatment of cancer induced bone pain, by evaluating the effectiveness and cost-effectiveness of MR-HIFU (alone or in combination with EBRT) compared to standard-of-care as a palliative treatment option to relieve cancer induced bone pain.
For more information on the aim of the project, visit the about the project page.